Enhancing glycan presentation increases vaccine efficacy
نویسندگان
چکیده
منابع مشابه
Enhancing cancer vaccine efficacy via modulation of the tumor microenvironment.
The development of therapeutic cancer vaccines is impacted by immunosuppressive elements in the tumor microenvironment. Most immunogenic cancer proteins are "self," therefore, peripheral tolerance contributes substantially to tumor immune escape. Transforming growth factor beta (TGFbeta) actively modulates both inflammation and tolerance induction. Combining vaccination with agents that disarm ...
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ژورنال
عنوان ژورنال: Nature Reviews Drug Discovery
سال: 2011
ISSN: 1474-1776,1474-1784
DOI: 10.1038/nrd3637